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Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo
Authors: Robert Verity, Nicholas J. Hathaway, Andreea Waltmann, Stephanie M. Doctor, Oliver J. Watson, Jaymin C. Patel, Kashamuka Mwandagalirwa, Antoinette K. Tshefu, Jeffrey A. Bailey, Azra C. Ghani, Jonathan J. Juliano, and Steven R. Meshnick
Source: Malaria Journal, 17:46; DOI: https://doi.org/10.1186/s12936-018-2193-9
Topic(s): Malaria
Maternal health
Women's health
Country: Africa
  Congo Democratic Republic
Published: JAN 2018
Abstract: Background The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiology of PAM, and in developing a robust vaccine against PAM. Methods Samples were taken from the 2013–14 Demographic and Health Survey conducted in the DRC, focusing on children under 5 years of age. A short subregion of the var2csa gene was sequenced in 115 spatial clusters, giving country-wide estimates of sequence polymorphism and spatial population structure. Results Results indicate that var2csa is highly polymorphic, and that diversity is being maintained through balancing selection, however, there is no clear signal of phylogenetic or geographic structure to this diversity. Linear modelling demonstrates that the number of var2csa variants in a cluster correlates directly with cluster prevalence, but not with other epidemiological factors such as urbanicity. Conclusions Results suggest that the DRC fits within the global pattern of high var2csa diversity and little genetic differentiation between regions. A broad multivalent VAR2CSA vaccine candidate could benefit from targeting stable regions and common variants to address the substantial genetic diversity.
Web: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2193-9


Debugging Information
ColdFusion Server Developer 2018,0,19,330149
Template /Publications/journal-details.cfm
Time Stamp 22-Jul-24 03:14 PM
Locale English (US)
User Agent Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
Remote IP 10.0.0.214
Host Name 10.0.0.214


Execution Time

Total Time Avg Time Count Template
1969 ms 82 ms 24 C:/inetpub/wwwroot/commonspot/utilities/ct-render-element.cfm
1954 ms 81 ms 24 C:/inetpub/wwwroot/commonspot/utilities/ct-render-element-core.cfm
1234 ms 1234 ms 1 C:/inetpub/wwwroot/commonspot/master.cfm
1234 ms 1234 ms 1 C:/inetpub/wwwroot/dhs/Publications/journal-details.cfm
1110 ms 1110 ms 1 C:/inetpub/wwwroot/commonspot/uncached-master.cfm
1110 ms 1110 ms 1 C:/inetpub/wwwroot/commonspot/utilities/cached-page-render.cfm
1094 ms 1094 ms 1 C:/inetpub/wwwroot/commonspot/master-render.cfm
1094 ms 1094 ms 1 C:/inetpub/wwwroot/commonspot/render-page-meat.cfm
1094 ms 1094 ms 1 C:/inetpub/wwwroot/commonspot/render-page.cfm
1000 ms 100 ms 10 C:/inetpub/wwwroot/commonspot/utilities/ct-render-named-element.cfm
1000 ms 1000 ms 1 C:/inetpub/wwwroot/dhs/templates/template-basepage.cfm
938 ms 938 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c1378-l70-t51-dAny.read
891 ms 891 ms 1 C:/inetpub/wwwroot/commonspot/utilities/run-element.cfm
657 ms 657 ms 1 C:/inetpub/wwwroot/commonspot/controls/customcf/cpe-customcf.cfm
500 ms 250 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/public_api/cache.cfc | getElementCacheSettings(9706, 4304) ] from C:/inetpub/wwwroot/commonspot/public_api/cache.cfc
110 ms 110 ms 1 C:/inetpub/wwwroot/dhs/customcf/legacy/journal/detail_article_summary.cfm
109 ms 109 ms 1 C:/inetpub/wwwroot/commonspot/set-page-vars.cfm
62 ms 62 ms 1 C:/inetpub/wwwroot/commonspot/render-head.cfm
62 ms 62 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/public_api/livebookmarks.cfc | getTags(9706) ] from C:/inetpub/wwwroot/commonspot/public_api/livebookmarks.cfc
47 ms 47 ms 1 C:/inetpub/wwwroot/commonspot/controls/control-setup.cfm
47 ms 47 ms 1 C:/inetpub/wwwroot/commonspot/controls/upfront-generic.cfm
47 ms 47 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/public_api/element.cfc | getInfo(elementTypeID = 26) ] from C:/inetpub/wwwroot/commonspot/public_api/element.cfc
31 ms 31 ms 1 C:/inetpub/wwwroot/commonspot/site-application.cfm
31 ms 31 ms 1 C:/inetpub/wwwroot/commonspot/startup/site-application-meat.cfm
31 ms 31 ms 1 C:/inetpub/wwwroot/dhs/Publications/Application.cfm
16 ms 16 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19155-l70-t51-dAny.read
16 ms 8 ms 2 C:/inetpub/wwwroot/commonspot/utilities/newwindow-js.cfm
16 ms 16 ms 1 C:/inetpub/wwwroot/dhs/custom-application.cfm
15 ms 15 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19153-l70-t51-dAny.read
15 ms 15 ms 1 C:/inetpub/wwwroot/commonspot/startup/core-application-meat.cfm
15 ms 15 ms 1 C:/inetpub/wwwroot/commonspot/startup/session-first-global.cfm
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c1432-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19152-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19154-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19169-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19172-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19174-l70-t51-dAny.read
0 ms 0 ms 1 C:/commonspot-data/customers/commonspot-users/sites/commonspot-site-dhs/mapped/cache/2/p9706-c19177-l70-t51-dAny.read
0 ms 0 ms 1 C:/inetpub/wwwroot/ADF/core/load_site_adf.cfm
0 ms 0 ms 2 C:/inetpub/wwwroot/commonspot/controls/ct-include-once.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/controls/dhtmlmenu/menu-output-display.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/controls/handle-styles.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/lview-contribute-mode-redirect-check.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/non-dashboard-include.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/pagemode/pagemodeui.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/render-body-tag.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/render-foot.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/render-metatags.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/render-tracking-code.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/security/security-page.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/browser-detect-methods.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/build-request-params.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/handle-head-request.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/handle-request-timeout.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/init-customer-scope.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/init-server-scope.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/startup/session-first-site.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/add-resource-request.cfm
0 ms 0 ms 6 C:/inetpub/wwwroot/commonspot/utilities/add-unregistered-resource-request.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/append-to-resource-group.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/build-user-struct.cfm
0 ms 0 ms 3 C:/inetpub/wwwroot/commonspot/utilities/cp-cfheader.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/cp-cfmail-request-queue.cfm
0 ms 0 ms 2 C:/inetpub/wwwroot/commonspot/utilities/define-upfront-vars.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/flush-cache-db-queue.cfm
0 ms 0 ms 4 C:/inetpub/wwwroot/commonspot/utilities/handle-in-list.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/load-template-properties.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/newwindow-js-meat.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/nocache-headers.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/update-page-cache-status.cfm
0 ms 0 ms 3 C:/inetpub/wwwroot/commonspot/utilities/validate-date-string.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/commonspot/utilities/verify-stub-data.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/dhs/custom-search/inc-custom-application-search-vars.cfm
0 ms 0 ms 1 C:/inetpub/wwwroot/dhs/templates/template-basepage.head
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc | getPageSettings(1) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc | getPageSettings(1652) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc | getPageSettings(2) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc | getPageSettings(9706) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-settings-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc | DBQueue_Count() ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc | GetPageCacheStatus(1652, 2, 2, 0) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc | GetPageCacheStatus(9706, 2, 1652, 0) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc | UpdateStatus(argumentCollection = [complex value]) ] from C:/inetpub/wwwroot/commonspot/components/cache/cache-status.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/custom-module-cache.cfc | getCustomAppPath(2) ] from C:/inetpub/wwwroot/commonspot/components/cache/custom-module-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/custom-module-cache.cfc | getCustomModulePath(post-page-render, 2) ] from C:/inetpub/wwwroot/commonspot/components/cache/custom-module-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/item-security-cache.cfc | GetEntry(9706) ] from C:/inetpub/wwwroot/commonspot/components/cache/item-security-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/rewrite-rules-cache.cfc | getRewriteSettings(2) ] from C:/inetpub/wwwroot/commonspot/components/cache/rewrite-rules-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/subsite-cache-manager.cfc | getLatest() ] from C:/inetpub/wwwroot/commonspot/components/cache/subsite-cache-manager.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/subsite-cache-manager.cfc | getSecurityPageIDMap([complex value]) ] from C:/inetpub/wwwroot/commonspot/components/cache/subsite-cache-manager.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/cache/template-cache.cfc | LoadTemplateProperties(publication-template.cfm, 1652, 2) ] from C:/inetpub/wwwroot/commonspot/components/cache/template-cache.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/custom-application-framework/handle-applications.cfc | executeFunction(handleRequestStart) ] from C:/inetpub/wwwroot/commonspot/components/custom-application-framework/handle-applications.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/engine/ACF/utilities.cfc | checkFileExists(C:/inetpub/wwwroot/dhs/templates/template-basepage.cfm, 0, false) ] from C:/inetpub/wwwroot/commonspot/components/engine/ACF/utilities.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/engine/ACF/utilities.cfc | queryRowToStruct(ArgumentCollection = [complex value]) ] from C:/inetpub/wwwroot/commonspot/components/engine/ACF/utilities.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/commonspot-context.cfc | getDSN(site) ] from C:/inetpub/wwwroot/commonspot/components/util/commonspot-context.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent('head' request check) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(CGI variable processing) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(New (global) session initialized) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(Request object updates) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(Request.Params initialized) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(RequestTimeout check) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(Server-level remote requests checked) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(Subsite context updated (ID=2)) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(authoring suspended check) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(basic setup) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(check for server property changes) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(core cleanup) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(core initialization) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(core variables) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(custom-application.cfm) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(customerScope object initialized) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(handleRequestStart) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(init-server-scope loaded) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(lock checks/updates) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(site environment initialization) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(site session check) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(subsite context refreshed) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(user object created) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(user session initialized) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(wait for lock: CommonSpot_Server_Scope (read)) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | addEvent(wait for lock: CommonSpot_Site1_Core (exclusive)) ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc | init() ] from C:/inetpub/wwwroot/commonspot/components/util/debug-timing.cfc
0 ms 0 ms 2 CFC[ C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc | getObject(Cache) ] from C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc | getObject(Element) ] from C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc | getObject(Keywords) ] from C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc | getObject(LiveBookmarks) ] from C:/inetpub/wwwroot/commonspot/components/util/object-factory.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/components/util/visitor-context-rule-actions.cfc | onPageVisit(9706, 2) ] from C:/inetpub/wwwroot/commonspot/components/util/visitor-context-rule-actions.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/public_api/keywords.cfc | appendEnforced(subsiteIDOrURL = , keywordList = Journal Details) ] from C:/inetpub/wwwroot/commonspot/public_api/keywords.cfc
0 ms 0 ms 1 CFC[ C:/inetpub/wwwroot/commonspot/udf/database.cfc | getUDF(commonspot-site-dhs) ] from C:/inetpub/wwwroot/commonspot/udf/database.cfc
0 ms  STARTUP, PARSING, COMPILING, LOADING, & SHUTDOWN
1265 ms  TOTAL EXECUTION TIME
red = over 250 ms average execution time


SQL Queries

get (Datasource=dhs_legacy_live, Time=16ms, Records=217) in C:\inetpub\wwwroot\dhs\custom-application.cfm @ 15:14:12.012
    	SELECT lang_text_var, lang_text_en
        FROM dataset_lang_dictionary
    
SelectedCustomRenderElements (Datasource=commonspot-site-dhs, Time=109ms, Records=2117) in C:\inetpub\wwwroot\commonspot\set-page-vars.cfm @ 15:14:12.012
		SELECT dcr.*
		  FROM Data_Custom_Render dcr, CustomElementModules cem
		 WHERE (dcr.PageID IN (?,?,?,?)) 
			AND dcr.VersionState=?
			AND (dcr.ModuleID = cem.ID OR dcr.ModuleID <= 0)
	 ORDER BY dcr.ControlID, dcr.PageID DESC, dcr.VersionID DESC
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1
Parameter #2(CF_SQL_INTEGER) = 2
Parameter #3(CF_SQL_INTEGER) = 1652
Parameter #4(CF_SQL_INTEGER) = 9706
Parameter #5(CF_SQL_INTEGER) = 2

Request.PageData.PageParams (Datasource=commonspot-site-dhs, Time=16ms, Records=1) in C:\inetpub\wwwroot\commonspot\render-page-meat.cfm @ 15:14:12.012
			SELECT *
			  FROM Param_Page
			 WHERE (PageID=9706 OR (PageID IN (1652,2,1) AND (VersionState = 2)))
			   AND VersionState=2
			 ORDER BY PageID DESC
		
qry (Datasource=commonspot-site-dhs, Time=31ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\core.cfm @ 15:14:12.012
					SELECT SubsiteID
					  FROM SitePages
					 WHERE ID = ? 
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

testQuery (Datasource=commonspot-site-dhs, Time=16ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:12.012
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

qry (Datasource=commonspot-site-dhs, Time=15ms, Records=0) in C:\inetpub\wwwroot\commonspot\commands\livebookmarks.cfc @ 15:14:12.012
		SELECT Data_SeeAlso.ID, SubSites.SubSiteURL, SitePages.filename as pagename,
				 XMLPublications.name as feedname, XMLPublicationFormat.name as feedformat,
				 XMLPublications.description,
				 CASE
					 	WHEN XMLPublicationFormat.IsSyndication = 0 THEN 0
						ELSE 1
				 END AS IsSyndicationFeed
		  FROM Data_SeeAlso, XMLPublications, XMLPublicationFormat, SitePages, SubSites
		 WHERE Data_SeeAlso.PageID = ?
		 	AND Data_SeeAlso.Action = ?
		 	AND Data_SeeAlso.ItemID = XMLPublicationFormat.XMLPublicationFormatID
		 	AND Data_SeeAlso.TargetPageID = XMLPublications.XMLPublicationID
		 	AND XMLPublications.XMLPublicationFormatID = XMLPublicationFormat.XMLPublicationFormatID
		 	AND XMLPublications.PageID = SitePages.ID
		 	AND SitePages.SubSiteID = SubSites.ID
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706
Parameter #2(CF_SQL_INTEGER) = 11

ControlInstanceData (Datasource=commonspot-site-dhs, Time=0ms, Records=76) in C:\inetpub\wwwroot\commonspot\controls\control-setup.cfm @ 15:14:12.012
		SELECT ControlID, ControlName, ControlType, ParentControlID, ParentControlType, pageID
		  FROM ControlInstance
		 WHERE (PageID IN (?,?,?,?)) 
	 ORDER BY ControlID, PageID DESC
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1
Parameter #2(CF_SQL_INTEGER) = 2
Parameter #3(CF_SQL_INTEGER) = 1652
Parameter #4(CF_SQL_INTEGER) = 9706

qInfo (Datasource=commonspot-site-dhs, Time=31ms, Records=1) in C:\inetpub\wwwroot\commonspot\commands\element.cfc @ 15:14:12.012
		SELECT ac.ShortDesc AS Name, CustomRenderSupport AS SupportsCustomLayouts,
				 CASE
					WHEN ac.ID <?
					 THEN 'Standard'
					WHEN (ac.Name is NULL or ac.Name = '')
					 THEN 'Saved'
					WHEN fcm.ClassID = 1
					 THEN 'Global'
					ELSE 'Local'
				 END AS ElementType,
				 CASE WHEN ac.Name = 'custom' THEN 'custom/ce' ELSE ac.ControlPrefix END AS ElementURLPrefix,
				 CASE WHEN (ac.ID IN (?,?,?,?,?,?,?,?,?,?,?,?))  THEN 0 ELSE 1 END AS HasFontColorProperties,
				 CASE WHEN (ac.ID IN (?,?,?,?,?,?,?))  THEN 0 ELSE 1 END AS HasLayoutProperties,
				 1 AS HasStyleProperties
		  FROM AvailableControls ac
		  LEFT OUTER JOIN FormControlMap fcm ON fcm.FormID = ac.ID
		 WHERE ac.ID = ? 
Query Parameter Value(s) -
Parameter #1(cf_sql_integer) = 400
Parameter #2(CF_SQL_INTEGER) = 22
Parameter #3(CF_SQL_INTEGER) = 44
Parameter #4(CF_SQL_INTEGER) = 55
Parameter #5(CF_SQL_INTEGER) = 1
Parameter #6(CF_SQL_INTEGER) = 56
Parameter #7(CF_SQL_INTEGER) = 47
Parameter #8(CF_SQL_INTEGER) = 26
Parameter #9(CF_SQL_INTEGER) = 48
Parameter #10(CF_SQL_INTEGER) = 27
Parameter #11(CF_SQL_INTEGER) = 28
Parameter #12(CF_SQL_INTEGER) = 51
Parameter #13(CF_SQL_INTEGER) = 31
Parameter #14(CF_SQL_INTEGER) = 33
Parameter #15(CF_SQL_INTEGER) = 26
Parameter #16(CF_SQL_INTEGER) = 48
Parameter #17(CF_SQL_INTEGER) = 37
Parameter #18(CF_SQL_INTEGER) = 27
Parameter #19(CF_SQL_INTEGER) = 38
Parameter #20(CF_SQL_INTEGER) = 28
Parameter #21(cf_sql_integer) = 26

Request.customCFUpfront (Datasource=commonspot-site-dhs, Time=47ms, Records=1) in C:\inetpub\wwwroot\commonspot\controls\upfront-generic.cfm @ 15:14:12.012
	SELECT *
	  FROM Data_CustomCF
	 WHERE (PageID=9706 OR (PageID IN (1652,2,1) AND (VersionState = 2)))
		AND (VersionState = 2) 
 ORDER BY ControlID, PageID DESC, VersionID DESC 
testQuery (Datasource=commonspot-site-dhs, Time=188ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

qry (Datasource=commonspot-site-dhs, Time=78ms, Records=1) in C:\inetpub\wwwroot\commonspot\commands\cache.cfc @ 15:14:13.013
		SELECT SubsiteID, InheritedTemplateList
		  FROM SitePages
		 WHERE ID=? 
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

testQuery (Datasource=commonspot-site-dhs, Time=47ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1652

testQuery (Datasource=commonspot-site-dhs, Time=63ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 2

testQuery (Datasource=commonspot-site-dhs, Time=15ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1

getArticlesDetails (Datasource=dhs_legacy_live, Time=47ms, Records=1) in C:\inetpub\wwwroot\dhs\customcf\legacy\journal\detail_article_summary.cfm @ 15:14:13.013
SELECT distinct(a.article_id),p.pub_id,tp.article_type_id,title,authors,article_date,article_year,
vol,link,active,source,pub_name,article_type_name,
abstract as abstractText
FROM dhs_articles a
INNER JOIN  Dhs_article_pub p ON a.pub_id = p.pub_id
INNER JOIN   Dhs_article_type Tp ON a.article_type_id = Tp.Article_type_Id

WHERE active=1	and tp.article_type_id=1

AND a.article_id =? 
Order By title
Query Parameter Value(s) -
Parameter #1(cf_sql_integer) = 2921

getart_topic (Datasource=dhs_legacy_live, Time=16ms, Records=3) in C:\inetpub\wwwroot\dhs\customcf\legacy\journal\detail_article_summary.cfm @ 15:14:13.013
				select * from dhs_article_topics_lnk l, dhs_article_topics t 
				where article_id=?
				and l.topic_id=t.topic_id
				order by topic_name
			 
Query Parameter Value(s) -
Parameter #1(cf_sql_integer) = 2921

getart_Ctry (Datasource=dhs_legacy_live, Time=47ms, Records=1) in C:\inetpub\wwwroot\dhs\customcf\legacy\journal\detail_article_summary.cfm @ 15:14:13.013
				select * from dhs_article_ctry_lnk l, dhs_article_ctry c ,dhs_article_rgn r
				where article_id=? and l.country_id=c.country_id
				and R.Rgn_id = c.country_rgn_id	
			 
Query Parameter Value(s) -
Parameter #1(cf_sql_integer) = 2921

testQuery (Datasource=commonspot-site-dhs, Time=15ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

qry (Datasource=commonspot-site-dhs, Time=16ms, Records=1) in C:\inetpub\wwwroot\commonspot\commands\cache.cfc @ 15:14:13.013
		SELECT SubsiteID, InheritedTemplateList
		  FROM SitePages
		 WHERE ID=? 
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 9706

testQuery (Datasource=commonspot-site-dhs, Time=16ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1652

testQuery (Datasource=commonspot-site-dhs, Time=47ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 2

testQuery (Datasource=commonspot-site-dhs, Time=0ms, Records=1) in C:\inetpub\wwwroot\commonspot\udf\validation\generated-validators.cfm @ 15:14:13.013
		SELECT ID
		  FROM SitePages
		 WHERE ID = ?
			AND (PageType IN (0,1,2) AND Uploaded=0)
	
Query Parameter Value(s) -
Parameter #1(CF_SQL_INTEGER) = 1


Scope Variables

Application Variables:
activesubsites=1,2,5,6,8,17,18,19,20,21,22,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58
adf=Struct (89)
adfscheduler=Struct (0)
applicationname=site1
assocpubdocs=Struct (4)
blogcache=Struct (4)
cachedimages=Struct (32)
cacheinfocache=Struct (53)
confidentiality=Array (5)
controlinstance_toplevel_cache=Struct (126)
covid_articlecount=10
covid_newsarticlecount=49
covid_pressreleasecount=4
covid_pubcount=3
cs_elementcache=Struct (10)
cs_resourcesmissing=Struct (0)
cs_rewriterulescache=Struct (21)
cs_subsitecachemanager=Struct (28)
customerinfo=Complex type
customerscope=Struct (21)
custommodulecache=Struct (21)
defaultconfidentiality=2
dhspagesyncdata=Struct (1)
itemsecuritycache=Struct (31)
languagenames=Struct (51)
languages=Struct (51)
lastknownchange=Struct (18)
lastupdate=Struct (14)
metadatacache=Struct (4)
pendingstubrequests=Struct (0)
rsscache=Struct (2)
search_archive_next_clean=2024-07-23 01:30:03
serverstatus=Struct (1)
site=Struct (74)
sitescope=Struct (9)
styleids=Struct (248)
stylenames=Struct (248)
subsitecache=Struct (46)
subsitecachebysecuritypageid=Struct (46)
templatecache=Struct (28)
templatedefaultsecuritycache=Struct (60)
templateenforcedsecuritycache=Struct (60)
treecache=Struct (25)
twittercache=Struct (2)
typefactory=Complex type
youtubecache=Struct (3)
CGI Variables:
AUTH_PASSWORD=
AUTH_TYPE=
AUTH_USER=
CERT_COOKIE=
CERT_FLAGS=
CERT_ISSUER=
CERT_KEYSIZE=
CERT_SECRETKEYSIZE=
CERT_SERIALNUMBER=
CERT_SERVER_ISSUER=
CERT_SERVER_SUBJECT=
CERT_SUBJECT=
CF_TEMPLATE_PATH=C:\inetpub\wwwroot\dhs\Publications\journal-details.cfm
CONTENT_LENGTH=0
CONTENT_TYPE=
CONTEXT_PATH=
GATEWAY_INTERFACE=CGI/1.1
HTTPS=off
HTTPS_KEYSIZE=
HTTPS_SECRETKEYSIZE=
HTTPS_SERVER_ISSUER=
HTTPS_SERVER_SUBJECT=
HTTP_ACCEPT=*/*
HTTP_ACCEPT_ENCODING=gzip, br, zstd, deflate
HTTP_ACCEPT_LANGUAGE=
HTTP_CONNECTION=
HTTP_COOKIE=
HTTP_HOST=preview.dhsprogram.com
HTTP_REFERER=
HTTP_URL=/Publications/journal-details.cfm?C_id=75&P_ID=0&T_ID=0&article_id=2921&r_id=0
HTTP_USER_AGENT=Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
LOCAL_ADDR=10.0.0.111
PATH_INFO=
PATH_TRANSLATED=C:\inetpub\wwwroot\dhs\Publications\journal-details.cfm
QUERY_STRING=C_id=75&P_ID=0&T_ID=0&article_id=2921&r_id=0
REMOTE_ADDR=10.0.0.214
REMOTE_HOST=10.0.0.214
REMOTE_USER=
REQUEST_METHOD=GET
SCRIPT_NAME=/Publications/journal-details.cfm
SERVER_NAME=preview.dhsprogram.com
SERVER_PORT=80
SERVER_PORT_SECURE=0
SERVER_PROTOCOL=HTTP/1.1
SERVER_SOFTWARE=Microsoft-IIS/10.0
WEB_SERVER_API=
Cookie Variables:
CSRFTOKEN=14A6593BAD368FD692608CD0D76C56C7832EE627
Request Parameters:
anonnoreadelements=
applockname=CS_App_Site1_1
archiveemail=archive@dhsprogram.com
assetsdir=/assets/
author_approve_whereclause=(VersionState = 2)
authormode=0
authorok=1
blupfront=
browser=Struct (13)
browserallincluded=1
cachefilesused=22
cachestatus=Complex type
cfflushcount=0
cgivars=Struct (49)
cloudfrontkeypairid=K3LSHNFSZFMIUC
cloudfronturl=d1vyaiefsqy4pf
constants=Complex type
cors.isCorsRequest=NO
cp=Struct (123)
cs_includedobjects=nwjs
cs_init_timings=Struct (23)
cs_isdashboardcmd=0
cs_request_start_memory=1063146848
cs_runningdashboardcmdcode=0
csrftoken=14A6593BAD368FD692608CD0D76C56C7832EE627
ctrl_data=Struct (64)
customcf_data=Struct (2)
customcfupfront=Query (1)
customerinfo=Complex type
customhead=1
customrenderhandlerpairs=
customsearch=Struct (11)
dbdsn=measure_db
debugstate=Struct (1)
dhspagesyncdata=Struct (1)
dhtmlmenuitemsprefetch=
disablehideformenus=0
dsource=dhs_legacy_live
editmode=0
element=Struct (42)
elementrundetail=Struct (1)
elementsrun=1
environment=Struct (5)
finalreportids=5,26,21,10,18,30,39
finalreportna=139,315,445,488,107,138,459,518
formattedtimestamp=2024-07-22 15:14:12
getghost=
hivbold=1,3,8,9
imageupfront=
imgdir=/images/
includerootdir=/
initialsiteid=1
initticks=1721661252510
jswarnmessage=
linkdataupfront_itempos=
linkdataupfront_itemtitle=
lockid=0
mainpage=Struct (84)
master_cfm_used=1
maxperms=Complex type
modeorderbyclause=VersionID Desc
modewhereclause=(VersionState = 2)
modewhereclause_page=(VersionState = 2)
multisectionupfront=
noauthorreason=
nocacheelementtypes=
nocacheheaderincluded=1
nondashboardincludedone=1
obcountires=EG,ZM
package=Struct (0)
page=Struct (84)
pagedata=Struct (1)
pagedhtmlitems=
pagedhtmlmenus=
pageperms=Complex type
pagesync=Struct (4)
params=Struct (9)
params_formfields=
params_urlfields=P_ID,C_id,article_id,T_ID,r_id
previewmode=0
readmodewhereclause=(VersionState = 2)
renderedelements=Struct (0)
renderelementdata=Struct (0)
renderfordiff=0
renderforprint=0
renderstate=Struct (73)
req_cam_callcount=1
req_inittimestamp=2024-07-22 15:14:12.510
req_sequenceid=291045
req_startticks=1721661252510
rootdir=/
rootpath=
rooturldatasetadmin=https://preview.dhsprogram.com/data/dataset_admin
samesite_value=
scheduleupfront=
serverdatasource=commonspot-sites
sessionlockname=Session_1_DB5821229677B13EEFD7170DC77987CB.cfusion
sessionstring=1_DB5821229677B13EEFD7170DC77987CB.cfusion
sicupfront=
sicupfrontparam=
site=Struct (74)
siteid=1
standardrenderhandlers=
styleids=Struct (248)
stylenames=Struct (248)
subsite=Struct (0)
subsitecache=Struct (46)
subsitecachebysecuritypageid=Struct (46)
subsiteid=2
taiupfrontparam=
tbupfront=
tbupfrontparam=
templatecachestatus=Struct (0)
templaterootdir=/
timestamp={ts '2024-07-22 15:14:12'}
trustcachestatus=1
typefactory=Complex type
udslockname=CS_Customer_commonspot-users
updatingschemas=0
user=Struct (30)
usersdatasource=commonspot-users
wanterrorsrethrown=0
warnmessage=
xmlbrowser=Struct (13)
Server Variables:
ADF=Struct (15)
COMMONSPOT=Struct (44)
EMAILALERTKEY=BSu0cRa8xSWdSrClnnGvpA==
SURVEYINFO_ACTIVE_DATE=2024-7-24
coldfusion=Struct (10)
os=Struct (5)
system=Struct (2)
Session Variables:
_csrf_token=14A6593BAD368FD692608CD0D76C56C7832EE627
adf=Struct (0)
authormode=0
contributemode=read
currentpageid=9706
debugmode=0
debugstate=Struct (1)
editmode=0
environment=Struct (5)
hasusertempfiles=0
language=Struct (216)
lastupdate=Struct (2)
lastuserupdate=1721661252525
lockid=0
lockobjectid=0
lockobjecttype=
locktype=
logintime=
ownedobjecttypes=
pendingapprovalpages=
pendingapprovals=
previewmode=0
requestedversioncounter=
requestedversiontimestamp=
sessionid=DB5821229677B13EEFD7170DC77987CB.cfusion
sessionstring=1_DB5821229677B13EEFD7170DC77987CB.cfusion
urltoken=CFID=3433733&CFTOKEN=a442465509db3d0e-8E119F83-B856-88F5-CCD8A08FB37F4464&jsessionid=DB5821229677B13EEFD7170DC77987CB.cfusion
usagelist=
user=Struct (30)
xmlbrowser=Struct (13)
xmlenvironment=Struct (5)
URL Parameters:
C_id=75
P_ID=0
T_ID=0
article_id=2921
r_id=0
Debug Rendering Time: 32 ms